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. 2016 Apr 26;18:94. doi: 10.1186/s13075-016-0992-3

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© Harrold et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Flowchart depicting the study cohort. MTX methotrexate, RA rheumatoid arthritis, nbDMARD nonbiologic disease-modifying antirheumatic drug. *Prior or current use of methotrexate only as nonbiologic DMARD. **Prior or current use of 2 or more nonbiologic DMARDS. ***For the MTX monotherapy group, limited to patients seen with moderate disease activity and poor prognosis or high disease activity and seen by a physician (not a midlevel provider) at both visits. For the multiple nonbiologic DMARD group, included only those patients with moderate or high disease activity seen by a physician (not a midlevel provider) at both visits