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. 2016 Apr 26;11:41. doi: 10.1186/s13000-016-0491-5

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© Guo et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Immunostaining of EZH2 in invasive breast carcinoma of different nuclear grade with variable intensity and quantity were shown. Low grade tubular carcinoma showed bland morphology with well formed tubules and mild atypia (a). A low level of EZH2 expression with only scattered positive cells was observed in tubular carcinoma (d). Invasive carcinoma, not otherwise specific type of nuclear grade 2 (b) with moderate atypia showed moderate expression of EZH2 (e). Poorly differentiated carcinoma of nuclear grade 3 was characterized with obvious atypia and solid growth pattern (c). Homogeneously strong expression of EZH2 was detected in poorly differentiated carcinoma (f). (Magnification × 100)