Table 2.
Clinicopathological characteristics of stage III undifferentiated gastric adenocarcinoma in terms of histology type
| Parameters | MC (n = 39) | SRCC (n = 261) | PDC (n = 581) | P value |
|---|---|---|---|---|
| Age (years), mean ± SD | 64.5 ± 10.0 | 60.2 ± 13.7 | 62.7 ± 14.0 | 0.019 |
| Median | 66.0 | 61.0 | 66.0 | |
| Sex | 0.002 | |||
| Male | 22 (56.4) | 128 (49.0) | 359 (61.8) | |
| Female | 17 (43.6) | 133 (51.0) | 222 (38.2) | |
| Tumor size (cm), mean ± SD | 7.6 ± 3.9 | 6.0 ± 3.7 | 5.8 ± 3.1 | 0.006 |
| Median | 7.0 | 5.0 | 5.0 | |
| Type of gastrectomy | 0.696 | |||
| Total | 13 (33.3) | 96 (36.8) | 226 (38.9) | |
| Subtotal | 26 (66.7) | 165 (63.2) | 355 (61.1) | |
| Extent of LN dissection | 0.268 | |||
| <D2 | 13 (33.3) | 71 (27.2) | 190 (32.7) | |
| ≥D2 | 26 (66.7) | 190 (72.8) | 391 (67.3) | |
| No. of LN retrieval, mean ± SD | 29.2 ± 16.3 | 30.2 ± 16.2 | 28.6 ± 14.9 | 0.373 |
| Median | 25.0 | 27.0 | 26.0 | |
| T status | 0.627 | |||
| T2 | 2 (5.1) | 6 (2.3) | 10 (1.7) | |
| T3 | 1 (2.6) | 5 (1.9) | 9 (1.5) | |
| T4 | 36 (92.3) | 250 (95.8) | 562 (96.8) | |
| LN status | ||||
| N0 | 2 (5.1) | 1 (0.4) | 13 (2.2) | 0.118 |
| N1 | 8 (20.5) | 41 (15.7) | 86 (14.8) | |
| N2 | 11 (28.2) | 52 (19.9) | 136 (23.4) | |
| N3 | 18 (46.2) | 167 (64.0) | 346 (59.6) | |
| Positive margins (R1 resection) | 8 (20.5) | 48 (18.4) | 84 (14.5) | 0.255 |
| Lymphatic invasiona | 0.442 | |||
| No | 8 (21.1) | 35 (13.5) | 88 (15.4) | |
| Yes | 30 (78.9) | 225 (86.5) | 484 (84.6) | |
| Vascular invasiona | 0.767 | |||
| No | 30 (78.9) | 204 (79.1) | 439 (76.9) | |
| Yes | 8 (21.1) | 54 (20.9) | 132 (23.1) | |
| Perineural invasiona | 0.003 | |||
| No | 17 (45.9) | 57 (22.2) | 175 (30.8) | |
| Yes | 20 (54.1) | 200 (77.8) | 394 (69.2) | |
| Complicationsb | 8 (20.5) | 44 (16.9) | 101 (17.4) | 0.854 |
| Surgery-related | 8 (20.5) | 35 (13.4) | 71 (12.2) | 0.316 |
| Leakage | 4 (10.3) | 19 (7.3) | 34 (5.9) | |
| Intra-abdominal abscess | 4 (10.3) | 12 (4.6) | 28 (4.8) | |
| Wound infection | 1 (2.6) | 4 (1.5) | 15 (2.6) | |
| Bleeding | 1 (2.6) | 8 (3.1) | 9 (1.5) | |
| Delayed gastric emptying | 0 | 1 (0.4) | 4 (0.7) | |
| Others | 0 | 3 (1.1) | 3 (0.5) | |
| Surgery unrelated | 1 (2.6) | 16 (6.1) | 48 (8.3) | 0.275 |
| Pneumonia | 0 | 2 (0.8) | 12 (2.1) | |
| Cardiovascular event | 0 | 5 (1.9) | 6 (1.0) | |
| Sepsis | 0 | 2 (0.8) | 7 (1.2) | |
| Paralytic ileus | 0 | 1 (0.4) | 4 (0.7) | |
| Atelectasis | 0 | 0 | 5 (0.9) | |
| Others | 1 (2.6) | 18 (6.9) | 38 (6.5) | |
| Hospital mortality | 2 (5.1) | 13 (5.0) | 32 (5.5) | 0.950 |
| Chemotherapy | 30 (76.9) | 205 (78.5) | 423 (72.8) | 0.197 |
Figures are numbers with percentages in parentheses, unless otherwise stated
LN lymph node, MC mucinous carcinoma, SD standard deviation, PDC poorly differentiated carcinoma, SRCC signet ring cell carcinoma
aSome data were missing
bNumber of patients with event