Table 3.
Univariate analysis of prognostic factors for stage III undifferentiated gastric adenocarcinoma
| Factors | Median survival (months) | 95 % CI for median | 3-year survival (%) | 5-year survival (%) | P value |
|---|---|---|---|---|---|
| Age (years) | 0.200 | ||||
| ≤65 (n = 449) | 23.8 | 20.4–27.3 | 39.2 | 29.2 | |
| >65 (n = 385) | 21.8 | 19.0–24.6 | 33.5 | 24.1 | |
| Sex | 0.374 | ||||
| Male (n = 474) | 21.8 | 19.1–24.6 | 34.7 | 25.8 | |
| Female (n = 360) | 25.2 | 21.3–29.2 | 38.3 | 28.6 | |
| Tumor size (cm) | 0.223 | ||||
| ≤5 (n = 410) | 28.4 | 23.9–33.0 | 43.1 | 32.9 | |
| >5 (n = 420) | 19.0 | 16.6–21.4 | 29.2 | 21.6 | |
| Type of gastrectomy | <0.0001 | ||||
| Total (n = 308) | 17.8 | 15.0–20.7 | 29.6 | 20.6 | |
| Subtotal (n = 526) | 26.6 | 23.1–30.1 | 40.1 | 30.7 | |
| Extent of LN dissection | 0.834 | ||||
| <D2 (n = 246) | 24.3 | 19.6–28.9 | 36.2 | 27.3 | |
| ≥D2 (n = 588) | 22.2 | 19.3–25.2 | 36.2 | 26.9 | |
| T status | 0.817 | ||||
| T1/T2 (n = 17) | 17.6 | 5.6–9.6 | 41.2 | 32.9 | |
| T3/T4 (n = 817) | 23.0 | 20.5–25.6 | 36.2 | 26.9 | |
| LN ratio | <0.0001 | ||||
| ≤0.34 (n = 416) | 38.7 | 30.8–46.7 | 52.4 | 41.9 | |
| >0.34 (n = 418) | 15.8 | 13.5–18.1 | 20.1 | 12.0 | |
| N status | <0.0001 | ||||
| N0 (n = 15) | NA | 57.8 | 57.8 | ||
| N1 (n = 129) | 65.3 | 29.5–101.1 | 58.9 | 50.3 | |
| N2 (n = 188) | 28.6 | 20.1–37.1 | 44.3 | 33.8 | |
| N3 (n = 52) | 18.8 | 16.7–0.9 | 26.5 | 17.3 | |
| Histology type | 0.038 | ||||
| MC (n = 37) | 47.8 | 0.0–103.0 | 51.1 | 48.1 | |
| SRCC (n = 248) | 20.8 | 16.5–25.0 | 36.9 | 26.0 | |
| PDC (n = 549) | 22.3 | 19.5–25.1 | 34.9 | 26.1 | |
| Resection margins | <0.0001 | ||||
| R0 (n = 709) | 25.4 | 22.4–28.3 | 39.8 | 30.1 | |
| R1 (n = 125) | 15.8 | 12.7–18.9 | 15.3 | 8.6 | |
| Lymphatic invasion | 0.006 | ||||
| No (n = 125) | 33.1 | 23.4–42.8 | 45.6 | 36.0 | |
| Yes (n = 698) | 21.5 | 19.5–23.6 | 34.1 | 25.0 | |
| Vascular invasion | 0.024 | ||||
| No (n = 635) | 24.3 | 21.7–26.9 | 37.2 | 28.1 | |
| Yes (n = 185) | 18.5 | 14.7–22.2 | 31.7 | 23.2 | |
| Perineural invasion | <0.0001 | ||||
| No (n = 234) | 31.4 | 19.1–43.8 | 46.9 | 40.4 | |
| Yes (n = 582) | 20.8 | 18.7–22.9 | 31.2 | 21.0 | |
| Chemotherapy | <0.001 | ||||
| No (n = 179) | 16.0 | 11.3–20.6 | 29.1 | 20.3 | |
| Yes (n = 655) | 24.5 | 22.0–27.0 | 38.1 | 28.7 |
CI confidence interval, LN ratios, ratios of metastatic to examined lymph nodes, MC mucinous carcinoma, PDC poorly differentiated carcinoma, SRCC signet ring cell carcinoma