Table 2. Effect of drug to polymer ratio on physicochemical characteristics and mucoadhesivity of sumatriptan combined with methoclopramide films/discs .
| Variables | Formulation code | |||||
| SM1 | SM2 | SM3 | SM4 | SM5 | SM6 | |
| Met :Sum: HPMC ratio | 1:2:8 | 1:2.7:8 | 1:4:8 | 1:4:6 | 1:4:10 | 1:4:14 |
|
Weight variation (mg ± SD) |
9.50 ± 2.50 | 11.01 ± 0.80 | 14.02 ± 1.20 | 99.85 ± 2.50 | 100.01 ± 2.80 | 99.02 ± 1.20 |
|
thickness (µm± SD) |
110.30 ± 0.03 | 123 ± 0.007 | 243 ± 0.05 | - | - | - |
|
Folding endurance (n±SD) |
>300±7 | >300±10 | 89 ± 12 | - | - | - |
|
Drug content (%±SD) |
Sum: 1.03 ± 0.33 | 1.15 ± 0.60 | 0.23 ± 0.02 | 15 ± 0.06 | 16.70 ± 0.23 | 19.90 ± 0.1 |
| Met: 0.59 ± 0.50 | 0.60 ± 0.80 | 0.57 ± 0.74 | 3.80 ± 0.06 | 4.30 ± 0.06 | 5.48 ± 0.06 | |
|
Loading Efficiency (%±SD) |
Sum: - | - | - | 94.53±3.58 | 62.64±1.58 | 41.25±1.32 |
| Met: - | - | - | 104.18±2.33 | 64.56±3.75 | 41.80±1.06 | |
|
Content uniformity (%±SD) |
Sum: 100 ± 0.02 | 98.59 ± 0.02 | 96.63 ±0.02 | 100 ± 0.12 | 97.49 ± 0.32 | 95.33 ± 0.22 |
| Met: 100 ± 0.01 | 99.9 ± 0.01 | 95.78 ± 0.06 | 100 ± 0.03 | 98.9 ± 0.01 | 94.59 ± 0.26 | |
|
Production Yield (%±SD) |
99.10 ± 9.1 | 100 ± 6.60 | 99.40 ± 2.30 | 107.33±3.78 | 88±9.16 | 69.66±6.65 |
|
Particle size (%±SD) |
- | - | - | 323.59±16.98 | 316.22±17.78 | 549.54±19.50 |
|
Absorbed moisture (% ± SD) |
0.79 ± 0.44 | 1.06 ± 0.95 | 4.52 ± 1.79 | - | - | - |
|
Moisture loss (% ± SD) |
0.79 ± 0.04 | 0.73 ± 0.08 | 2.85 ± 0.66 | - | - | - |
|
Surface pH (±SD) |
6.6 ± 0.2 | 6.8 ± 0.1 | 6.9 ± 0.1 | 6.8 ± 0.00 | 6.8 ± 0.04 | 6.8 ± 0.02 |
|
Swelling index (%±SD) |
19.85 ± 0.02 | 20 ± 0.01 | 14.18 ± 0.02 | 15.67 ± 0.82 | 16.20 ± 0.17 | 17.47 ± 0.41 |
|
Mucoadhesive strength (g/cm2±SD) |
134.81 ± 13.1 | 127.61 ± 8.4 | 120.50 ± 6.6 | 0.8 ± 0.16 | 1.11± 0.16 | 1.38 ± 0.09 |
|
Residence time (min±SD) |
0.42 ± 0.002 | 0.33 ± 0.014 | 0.5 ± 0.004 | 61± 12.77 | 78 ± 19.67 | 130 ± 8.86 |