Table 1. Formulation batches by a) high pressure homogenization technique (First generation approach) and b) H96 process (Lyophilization + HPH) .
| Formulation code | Formulation Composition | |||||
|
Aprepitant
(mg) |
Tween 80
(%w/v) |
Poloxamer 188 (%w/v) | PVA (%w/v) | SLS (%w/v) | Batch Size (ml) | |
| a) Formulation batches by high pressure homogenization technique (First generation approach) | ||||||
| NCH1 | 125 | 0.25 | - | - | - | 40 |
| NCH2 | 125 | 0.5 | - | - | - | 40 |
| NCH3 | 125 | 1 | - | - | - | 40 |
| NCH4 | 125 | 2 | - | - | - | 40 |
| NCH5 | 125 | 3 | - | - | - | 40 |
| NCH6 | 125 | - | 0.25 | - | - | 40 |
| NCH7 | 125 | - | 0.5 | - | - | 40 |
| NCH8 | 125 | - | 1 | - | - | 40 |
| NCH9 | 125 | - | 2 | - | - | 40 |
| NCH10 | 125 | - | 3 | - | - | 40 |
| NCH11 | 125 | - | - | 0.25 | - | 40 |
| NCH12 | 125 | - | - | 0.5 | - | 40 |
| NCH13 | 125 | - | - | 1 | - | 40 |
| NCH14 | 125 | - | - | 2 | - | 40 |
| NCH15 | 125 | - | - | 3 | - | 40 |
| NCH16 | 125 | - | - | - | 0.25 | 40 |
| NCH17 | 125 | - | - | - | 0.5 | 40 |
| NCH18 | 125 | - | - | - | 1 | 40 |
| NCH19 | 125 | - | - | - | 2 | 40 |
| NCH20 | 125 | - | - | - | 3 | 40 |
| NCH21 | 125 | 1 | 3 | - | - | 40 |
| NCH22 | 125 | 1 | - | 0.25 | - | 40 |
| NCH23 | 125 | 1 | - | - | 3 | 40 |
| b) Formulation batches by H96 process (Lyophilization + HPH) | ||||||
| NCLH1 | 125 | 1 | - | - | - | 40 |
| NCLH2 | 125 | - | 3 | - | - | 40 |
| NCLH3 | 125 | - | - | 0.25 | - | 40 |
| NCLH4 | 125 | - | - | - | 3 | 40 |
| NCLH5 | 125 | 1 | 3 | - | - | 40 |
| NCLH6 | 125 | 1 | - | 0.25 | - | 40 |
| NCLH7 | 125 | 1 | - | - | 3 | 40 |