Table 4. Saturation Solubility of pure drug and aprepitant nanocrystals .

Medium	Pure drug Concentration (µg/ml) (Mean ± SD)	Nanocrystals Concentration (µg/ml) (Mean ± SD)	Fold increase in saturation solubility
Distilled water	2.90 ± 0.53	43.1 ± 5.10	14.86
pH 1.2 buffer + 2.2%w/v SLS	2736 ± 30.38	3314 ± 10.99	1.21
pH 4.6 buffer + 2.2%w/v SLS	3364 ± 12.59	3854 ± 8.17	1.15
Phosphate buffer pH6.8	3.4 ± 2.38	38.6 ± 3.94	11.35
Phosphate buffer pH7.4	3.52 ± 1.22	40.2 ± 5.10	11.42
2.2%w/v SLS in water	3910 ± 31.40	4610 ± 7.21	1.18