Table 5. Percentage enhancement of dissolution of aprepitant nanocrystals as compared to pure drug at 45 minutes .

Dissolution medium	%CDR at 45 minutes (Mean±SD)		Fold enhancement of dissolution of nanocrystal
	Pure drug	Nanocrystals
2.2%w/v SLS	50.52 ± 1.05	100.05 ± 0.53	1.98
pH 1.2 HCl buffer + 2.2% w/v SLS	29.52 ± 0.55	85.05 ± 0.75	2.88
pH 4.6 acetate buffer + 2.2% w/v SLS	43.59 ± 0.55	88.05 ± 1.75	2.01
pH 6.8 phosphate buffer + 2.2% w/v SLS	49.18 ± 2.55	99.03 ± 1.83	2.01
pH 7.4 phosphate buffer + 2.2% w/v SLS	48.11 ± 1.13	100.93 ± 0.65	2.09