Table 2.
Comparison of Chromosomal Aberrations in CLL With and Without 2p25.3 Gain Detected by aCGHa
| Chromosome | With 2p25.3 Gain | Without 2p25.3 Gain | P Value |
|---|---|---|---|
| del 17p13.1(FISH) | 11/35 (31.4%) | 28/133 (21.1%) | .285 |
| del 11q23 (FISH) | 15/35 (42.9 %) | 22/133 (16.5%) | .002 |
| del 13q14 (FISH) | 21/35 (60%) | 26/133 (19.5%) | < .0001 |
| Trisomy 12 (FISH) | 4/35 (11.4%) | 23/133 (17.3%) | .561 |
| del 6q (aCGH) | 15/45 (33.3%) | 14/133 (13.5%) | .001 |
| del 14q (aCGH) | 16/45 (35.6%) | 17/133 (12.8%) | .001 |
| Unmutated IGHV | 26/34 (76.5%) | 52/133 (39.1%) | < .0001 |
| ZAP-70 expression | 19/27 (70.4%) | 19/56 (33.9%) | .002 |
Abbreviations: aCGH = array-based comparative genomic hybridization; CLL = chronic lymphocytic leukemia; FISH = fluorescent in situ hybridization.
a
Chromosomal aberrations were detected by aCGH. IGHV somatic hypermutation status was evaluated by Sanger sequencing. Mutated IGHV is defined as ≥2% mutated bases in the sequenced region. ZAP-70 expression was detected by flow cytometry. P values were calculated using chi-square test.