Table 6.
cytotoxicity (IC50, µM) |
antibacterial activity (MIC, µg/mL) |
|||||||
---|---|---|---|---|---|---|---|---|
SF295 | H226 | SF539 | M14 | MDA-MB-468 | S. aureus | B. subtilis | M. smegmatis | |
1 | 3.1±0.1 | 7.2±0.4 | 12±2 | 31±6 | 52±1 | >100 | >100 | >100 |
5 | >100 | >100 | >100 | >100 | >100 | >100 | 85 | 93 |
15 | 12±1 | 7.2±0.5 | 3.2±0.2 | 2.4±0.1 | 16±1 | 11 | 8.1 | 9.7 |
16 | 17±1 | 4.6±0.3 | 10±1 | 9.7±0.6 | 27±1 | >100 | 25 | >100 |
mitomycin C | 0.54±0.01 | 0.58±0.02 | (3.8±0.3)×10−2 | 0.47±0.01 | 0.50±0.02 | N | N | N |
tetracycline | N | N | N | N | N | 6.7 | 13 | 11 |
“N” indicates compounds not tested.