. Author manuscript; available in PMC: 2016 Oct 23.

Published in final edited form as: J Nat Prod. 2015 Sep 3;78(10):2471–2480. doi: 10.1021/acs.jnatprod.5b00601

Table 6.

Cytotoxicity and Antibacterial Assays for 1, 5, 15 and 16

	cytotoxicity (IC₅₀, µM)					antibacterial activity (MIC, µg/mL)
	SF295	H226	SF539	M14	MDA-MB-468	S. aureus	B. subtilis	M. smegmatis
1	3.1±0.1	7.2±0.4	12±2	31±6	52±1	>100	>100	>100
5	>100	>100	>100	>100	>100	>100	85	93
15	12±1	7.2±0.5	3.2±0.2	2.4±0.1	16±1	11	8.1	9.7
16	17±1	4.6±0.3	10±1	9.7±0.6	27±1	>100	25	>100
mitomycin C	0.54±0.01	0.58±0.02	(3.8±0.3)×10⁻²	0.47±0.01	0.50±0.02	N	N	N
tetracycline	N	N	N	N	N	6.7	13	11

“N” indicates compounds not tested.