Table 3.
Associations of each adipokine with transformed CFPWV (−1000/CFPWV)
Model 1* | Model 2† | Model 3§ | ||||
---|---|---|---|---|---|---|
Adipokine | Regression coefficient. per SD (95%CI) | P Value | Regression coefficient. per SD (95%CI) | P Value | Regression coefficient. per SD (95%CI) | P Value |
RBP4 | 0.58 (−0.08,1.23) | 0.09 | 0.60 (−0.06,1.25) | 0.08 | 0.58 (−0.08,1.25) | 0.09 |
A-FABP | 1.14 (0.54,1.73) | 0.0002 | 0.96 (0.25,1.67) | 0.008 | 0.88 (0.16,1.60) | 0.02 |
Leptin | −0.03 (−0.70,0.64) | 0.93 | −1.06 (−1.95,−0.18) | 0.02 | −1.22 (−2.12,−0.32) | 0.008 |
LEP-R | −0.79 (−1.35,−0.24) | 0.005 | −0.65 (−1.21,−0.08) | 0.02 | −0.65 (−1.21,−0.08) | 0.03 |
Adiponectin | 0.22 (−0.54,0.97) | 0.57 | 0.38 (−0.40,1.15) | 0.34 | 0.47 (−0.31,1.25) | 0.24 |
Beta coefficient per standard deviation (SD) of sex standardized biomarkers as in Table 1.
Model 1: adjusted for age, sex, heart rate, height, anti-hypertensive treatment, total and HDL cholesterol, smoking, diabetes and mean arterial pressure.
Model 2: adjusted for Model 1 covariates and body weight.
Model 3: adjusted for Model 2 covariates plus estimated glomerular filtration, alcohol, glucose, log transformed c reactive protein.
Abbreviations: LEP-R- leptin receptor, A-FABP- fatty acid binding protein 4, RBP4- retinol binding protein 4, CFPWVcarotid femoral pulse wave velocity, m/s- meters per second