FIG. 4.
LDL-C cholesterol concentration increases on therapy in HCV-monoinfected subjects. Total cholesterol and serum LDL-C concentrations change during HCV therapy with SOF/LDV combined with GS-9541 or GS-9669 for 6 weeks in HCV-monoinfected subjects (A, B) while HDL-C and triglyceride values are unchanged (C, D). Shown are individual values and means with standard error (A–D) (n = 31). p-values represent values significantly different by one-way ANOVA with a multiple t-test correction test for values in relation to baseline values (week 0). EOT, end of treatment (week 6).