Skip to main content
. Author manuscript; available in PMC: 2016 Apr 26.
Published in final edited form as: Mol Psychiatry. 2013 Oct 22;19(3):311–316. doi: 10.1038/mp.2013.133

Figure 2.

Figure 2

Working memory deficits in COMT*dys double knockout mice. (a) Latency to retrieve the hidden food pellet displayed by catechol-O-methyl transferase (COMT) single ko mice, dys single ko mice and COMT*dys double ko mice during the discrete paired-trial T-maze task. N = 11–16/group. All mice readily learned to run through the maze to retrieve the food reward independently of their COMT and/or dys genotype indicating that COMT, dys and their interaction did not alter reference memory components of this T-maze task. (b) Days needed to reach criteria displayed by wild-type (COMT+/+ dys+/+), COMT knockouts (COMT+/− dys+/+; COMT−/− dys+/+), dys knockouts (COMT+/+ dys+/−; COMT+/+ dys−/−) and COMT*dys double knockout (COMT+/− dys+/−; COMT−/− dys−/−) littermates during the discrete paired-trial T-maze task. Values represent mean±s.e.m. N = 9–16/group; *P < 0.05 versus wild-type (COMT+/+ dys+/+) littermates.