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. Author manuscript; available in PMC: 2016 Jun 16.
Published in final edited form as: Nature. 2015 Dec 16;528(7583):580–584. doi: 10.1038/nature16162

Figure 1. Schematic overview of the computational design method.

Figure 1

The lengths of each helix and loop were systematically enumerated. For each choice of helix and loop lengths, individual repeat units (red boxes on right) were built up from fragments of proteins of known structure, and then propagated to generate extended repeating structures (gray) with right-handed or left-handed twist.