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. Author manuscript; available in PMC: 2016 Jun 16.
Published in final edited form as: Nature. 2015 Dec 16;528(7583):580–584. doi: 10.1038/nature16162

Extended Data Figure 5. Superposition between single internal repeats (second repeat) of designs (grey) and crystal structures (yellow).

Extended Data Figure 5

Aliphatic and aromatic side chains are in red and cysteines are in orange. DHR7 and 18 show intra repeat disulphide bonds while DHR4 and 81 form inter-repeat cystines. DHR5 does not form the expected S-S bond. Core side chains in design recapitulate the conformation observed in the crystal structures. Even when the backbone is shifted (e.g. DHR5, 8, 15), rotamers are by large correctly predicted.