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. Author manuscript; available in PMC: 2016 Apr 26.
Published in final edited form as: J Am Chem Soc. 2015 Apr 22;137(17):5741–5747. doi: 10.1021/ja513117p

Figure 7.

Figure 7

Induction of γH2AX by 3 and 1 is ATM dependent. Immunofluorescence imaging of γH2AX and 53BP1 foci in K562 cells treated with 1 μM 3 or 0.5 nM 1 in the presence or absence of 10 μM KU55933. Rows (top to bottom): γH2AX (green), 53BP1 (red), DNA (blue), and merge. Columns (left to right): control, 0.5 nM 1, 1 μM 3, 10 μM KU55933, 0.5 nM 1 + 10 μM KU55933, 1 μM 3 + 10 μM KU55933. Cells were exposed to KU55933 for 1 h prior to addition of 1 or 3; exposure was 1 h.