Table 2.
Baseline Characteristics in HP patients with and without Autoimmune Features
| Characteristics | HPAF (n=18) |
HP without AF (n=102) |
p-value |
|---|---|---|---|
| Age, mean (±SD) | 62.2 (9.5) | 62.7 (10.5) | 0.858 |
| Female gender, n (%) | 15 (83.3) | 55 (53.9) | 0.020 |
| Race/Ethnicity | |||
| Caucasian, n (%) | 13 (72.2) | 87 (85.3) | 0.170 |
| Hispanic, n (%) | 1 (5.6) | 9 (8.8) | 1.000 |
| African American, n (%) | 2 (11.1) | 5 (4.9) | 0.282 |
| Asian, n (%) | 2 (11.1) | 1 (0.98) | 0.059 |
| BMI, mean (±SD) | 31.1 (8.2) | 32.6 (8.0) | 0.470 |
| Ever smoker, n (%) | 8 (44.4) | 62 (60.8) | 0.195 |
| Chronic systemic corticosteroid use, n (%) | 16 (61.5) | 70 (74.5) | 0.195 |
| Other immunosuppressive therapy, n (%) | 5 (27.8) | 31 (30.4) | 0.823 |
| Antigen exposure | |||
| Avian, n (%) | 8 (44.4) | 48 (47.1) | 0.838 |
| Mold, n (%) | 6 (33.3) | 29 (28.4) | 0.673 |
| Hot tub, n (%) | 0 (0) | 3 (2.9) | 0.611 |
| Unknown, n (%) | 4 (22.2) | 34 (33.3) | 0.350 |
| Gastroesophageal reflux, n (%) | 13 (72.2) | 58 (56.9) | 0.222 |
| Coronary artery disease, n (%) | 4 (22.2) | 21 (20.6) | 0.875 |
| Crackles, n (%) | 15 (83.3) | 87 (85.3) | 0.830 |
| Clubbing, n (%) | 1 (5.6) | 28 (27.5) | 0.045 |
HP = Hypersensitivity Pneumonitis; HPAF= HP with Autoimmune features as defined in the text; AF = Autoimmune features