Table 3.
Assessment of Lung Function, HRCT and Pathologic Characteristics in HP
| Characteristics | HPAF (n=18) |
HP without AF (n=102) |
p-value |
|---|---|---|---|
| Pulmonary Function Tests | |||
| TLC‘ (% predicted) (±SD) | 72.9 (16.0) | 72.3 (18.4) | 0.889 |
| FVC@ (% predicted) (±SD) | 63.7 (20.3) | 65.1 (18.7) | 0.773 |
| DLCO (% predicted) (±SD) | 55.1 (26.7) | 54.3 (24.2) | 0.906 |
| Oxygen therapy, n (%) | 7 (38.9) | 61 (59.8) | 0.099 |
| 6MWT distance (feet) (±SD) | 1004.3 (424) | 1120.0 (451) | 0.328 |
| HRCT features | |||
| HRCT fibrosis score, mean (±SD) | 123.3(14.0) | 124.0(17.4) | 0.862 |
| Mosaic attenuation, n (%) | 15 (83.3) | 88 (86.3) | 0.741 |
| Centrilobular nodules, n (%) | 11 (61.1) | 40 (39.2) | 0.083 |
| Ground glass opacities, n (%) | 17 (94.4) | 97 (95.1) | 0.631 |
| Reticulation, n (%) | 14 (77.8) | 78 (76.5) | 1.000 |
| Traction bronchiectasis, n (%) | 14 (77.8) | 84 (82.4) | 0.644 |
| Honeycombing, n (%) | 7 (38.9) | 43 (42.2) | 0.795 |
| Absence of lower zone predominant fibrosis, n (%) | 10 (55.6) | 59 (57.8) | 0.856 |
| Histopathologic features | |||
| Surgical lung biopsy obtained, n (%) | 14 (77.8) | 60 (58.8) | 0.127 |
| Poorly formed granulomas, n (%) | 11 (78.6) | 37 (61.7) | 0.233 |
| Lymphoplasmacytic infiltration/GC, n (%) | 6 (42.9) | 13 (21.7) | 0.170 |
| Honeycombing with UIP pattern, n (%) | 7 (50.0) | 28 (46.7) | 0.822 |
HP = Hypersensitivity Pneumonitis; HPAF= Hypersensitivity Pneumonitis with Autoimmune features as defined in the text; AF = Autoimmune features;
‘
n=112;
@
n=114; 6MWT = 6 minute walk test, n=109; HRCT= High-resolution computerized tomography scan; GC = Germinal centers