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. 2015 Sep 25;34(1):79–87. doi: 10.1097/HJH.0000000000000732

FIGURE 3.

FIGURE 3

Effect of rs7164338 minor allele (C) on three analysed ‘omics’. We observed that rs7164338 minor allele was significantly associated (dark blue arrows) with lower (red arrow) methylation of CIB2 promoter region and increased (green arrow) CIB2 expression. We also reported a causal relationship between DNA methylation and CIB2 expression. We hypothesized (dashed light blue arrows) that increased levels of CIB2 expression in the individuals carrying the C allele may lead to increased arterial calcification (light blue arrow) and result in decrease (red arrow) of PWV observed in the GWA analysis. CIB2, calcium and integrin-binding protein-2; GWA, genome-wide association; PWV, pulse wave velocity.