Table 2.
Results of Poisson Regression Analysis of Variables Associated With 30-Day Mortality and Delayed Appropriate Therapy
| Variable | Unadjusted |
Adjusted |
||
|---|---|---|---|---|
| RR (95% CI) |
P Value |
RR (95% CI) |
P Value |
|
| 30-Day Mortality | ||||
| Delayed appropriate therapy (≥48.1 h) | 3.10 (1.88–5.12) | <.001 | 3.16 (1.96–5.09) | <.001 |
| Charlson comorbidity index >4a | 3.10 (1.17–8.2) | .009 | 3.00 (1.16–7.80) | .024 |
| Prosthetic device or hardware | 2.58 (1.35–4.93) | .032 | 2.50 (1.19–5.24) | .016 |
| Pitt bacteremia score ≥4b | 2.01 (1.20–3.37) | .021 | 1.76 (1.09–2.84) | .021 |
| Age ≥54 y | 2.56 (1.07–6.12) | .018 | … | … |
| Unknown primary EBSI source | 1.89 (1.03–3.48) | .059 | … | … |
| Chronic hemodialysis | 1.46 (.87–2.45) | .152 | … | … |
| Chemotherapy/radiation therapy (30 d) | 1.81 (.95–3.45) | .096 | … | … |
| Mechanical ventilationa | 1.92 (1.13–3.27) | .021 | … | … |
| Malignancy | 1.65 (.93–2.90) | .099 | … | … |
| Ampicillin-resistant phenotype | 1.42 (.84–2.39) | .184 | … | … |
| Source control pursued | 0.56 (.33–.95) | .029 | … | … |
| Delayed Therapy | ||||
| Vancomycin-resistant phenotype | 2.92 (1.52–5.61) | <.001 | 3.44 (1.86–6.35) | <.001 |
| ID consult within 24 h following index culture | 0.48 (.30–.79) | .003 | 0.41 (.26–.64) | <.001 |
| Daptomycin-nonsusceptible phenotypec | 2.23 (1.22–4.11) | .055 | … | … |
| Prior hospitalization (1 y) | 2.01 (1.02–3.96) | .029 | … | … |
Abbreviations: CI, confidence interval; EBSI, enterococcal bloodstream infection; ID, infectious diseases; RR, risk ratio.
a At time of index culture.
b Worst score in 48 hours preceding index culture.
c Withheld from final model due to Hessian matrix singularity.