Table 1. Total genomic disruption in relation to clinical and histopathological variables.
| Independent variable | Descriptive statistics | Hypothesis testing p-value |
|---|---|---|
| Age at diagnosis (months) | Mean ± SEM | <2.20E-016* (WRST) |
| Q1 (25% least disrupted tumors) | 8 ± 1.4 months | |
| Q2 | 14 ± 1.8 months | |
| Q3 | 26 ± 2.6 months | |
| Q4 (25% most disrupted tumors) | 38 ± 3.4 months | |
| Laterality | # genes with SCNAs: | 8.16E-008* (WRST) |
| bilateral | 1267 ± 230 genes | |
| unilateral | 2845 ± 223 genes | |
| Heredity | # genes with SCNAs: | 0.0045* (WRST) |
| hereditary | 1618 ± 252 genes | |
| non-hereditary | 2752 ± 285 genes | |
| Differentiation grade | # genes with SCNAs: | 0.046* (LBL) |
| well | 1998 ± 490 genes | |
| moderate | 3307 ± 523 genes | |
| poor | 3556 ± 420 genes | |
| FW-rosettes | # genes with SCNAs: | 0.048 (WRST) |
| yes | 1293 ± 327 genes | |
| no | 2661 ± 844 genes | |
| Focality | # genes with SCNAs: | 0.1144 (WRST) |
| multifocal | 1016 ± 157 genes | |
| unifocal | 2650 ± 658 genes | |
| Volume measured by MRI (mm3) | Mean ± SEM | 0.1828 (WRST) |
| Q1 (25% least disrupted tumors)Q2 | 1028 ± 91 mm3976 ± 123 mm3 | |
| Q3 | 773 ± 153 mm3 | |
| Q4 (25% most disrupted tumors) | 1120 ± 173 mm3 | |
| Sex | # genes with SCNAs: | 0.2191 (WRST) |
| male | 2732 ± 278 genes | |
| female | 2231 ± 228 genes | |
| Rosettes | # genes with SCNAs: | 0.4004 (WRST) |
| yes | 1325 ± 225 genes | |
| no | 2303 ± 986 genes | |
| Familiarity | # genes with SCNAs: | 0.4437 (WRST) |
| familial | 1045 ± 651 genes | |
| non-familial | 1507 ± 220 genes | |
| Invasion | # genes with SCNAs: | 0.5951 (WRST) |
| invasive | 3094 ± 326 genes | |
| non-invasive | 2939 ± 457 genes |
Tested variables are sorted by statistical significance. Q1-4 denote cohort quartiles based on the number of genes whose copy number is altered where Q1 denotes the cohort quartile with the least copy number altered genes and Q4 the cohort quartile with the most copy number altered genes. WRST-Wilcoxon rank-sum test, LBL = Linear-by-linear.
* indicates significance (p-value < 0.05). P-values lower than 0.001 are given in scientific notation.