Table S3.

Drug–drug interactions in Case #3

	Impact	Action	Mechanism
Drug–gene interactions
None	N/A	N/A	N/A
Drug–drug interactions based on CYP450 metabolism
Amiodarone HCl and losartan potassium	Moderate	Monitor therapy	CYP2C8 inhibitors (moderate) may decrease the metabolism of CYP2C8 substrates (amiodarone)
Diltiazem HCl and fluticasone/vilanterol	Moderate	Monitor therapy	CYP3A4 inhibitors (diltiazem) may decrease the metabolism of CYP3A4 substrates (fluticazone)
Diltiazem HCl and lidocaine	Moderate	Monitor therapy	CYP3A4 inhibitors (diltiazem) may decrease the metabolism of CYP3A4 substrates
Non-CYP450 drug–drug interactions
Albuterol sulfate and amiodarone HCl	Major	Consider modification	QTc-prolonging agents may enhance the QTc-prolonging effect of highest risk QTc-prolonging agents
Amiodarone HCl and dabigatran etexilate mesylate	Major	Consider modification	Amiodarone may increase the serum concentration of dabigatran etexilate
Amiodarone HCl and digoxin	Major	Consider modification	Amiodarone may increase the serum concentration of cardiac glycosides
Amiodarone HCl and diltiazem HCl	Major	Consider modification	Calcium channel blockers may enhance the bradycardic effect of amiodarone. Sinus arrest has been reported
Amiodarone HCl and fluticasone/vilanterol	Major	Consider modification	QTc-prolonging agents may enhance the QTc-prolonging effect of highest risk QTc-prolonging agents

Abbreviations: N/A, not available; QTc, corrected QT.