Table 2.
Analysis of signaling pathways associated with differential expression of cytokines induced by SPOP knockdown
| Signaling pathway | P-value |
|---|---|
| Integrin cell surface interactions | 7.05E-05 |
| Extracellular matrix organization | 1.11E-04 |
| Immunoregulatory interactions between a lymphoid and a non-lymphoid cell | 0.002 |
| TNF signaling pathway | 0.002 |
| Leukocyte transendothelial migration | 0.003 |
| EPH-ephrin signaling | 0.003 |
| Bladder cancer | 0.004 |
| Degradation of the extracellular matrix | 0.005 |
| VEGF ligand–receptor interactions | 0.008 |
| VEGF binds to VEGFR leading to receptor dimerization | 0.008 |
| Apoptotic cleavage of cell adhesion proteins | 0.010 |
| Alzheimer disease-presenilin pathway | 0.013 |
| Alpha9 beta1 integrin signaling events | 0.013 |
| NF-kappa B signaling pathway | 0.019 |
| Rheumatoid arthritis | 0.019 |
| Syndecan-4-mediated signaling events | 0.020 |
| Cytokine–cytokine receptor interaction | 0.022 |
| Interleukin receptor SHC signaling | 0.025 |
| Adherens junctions interactions | 0.028 |
| Plasminogen activating cascade | 0.028 |
| Activation of matrix metalloproteinases | 0.028 |
| VEGFR2-mediated cell proliferation | 0.028 |
| EPHA-mediated growth cone collapse | 0.029 |
| Cytokine signaling in immune system | 0.031 |
| Apoptotic cleavage of cellular proteins | 0.033 |
| Axon guidance mediated by Slit/Robo | 0.033 |
| Nuclear signaling by ERBB4 | 0.034 |
| Sumoylation as a mechanism to modulate ctbp-dependent gene responses | 0.038 |
| Axon guidance | 0.038 |
| Interleukin-2 signaling | 0.041 |
| Pertussis toxin-insensitive ccr5 signaling in macrophage | 0.042 |
| G beta:gamma signaling through PI3K gamma | 0.042 |
| Interleukin-3 and -5 and GM-CSF signaling | 0.043 |
| Cell adhesion molecules | 0.043 |
| EPH-ephrin-mediated repulsion of cells | 0.044 |
| Apoptotic execution phase | 0.045 |
| GPVI-mediated activation cascade | 0.045 |
| G-protein beta:gamma signaling | 0.045 |
| G-protein signaling through tubby proteins | 0.046 |
| Assembly of collagen fibrils and other multimeric structures | 0.048 |
Abbreviations: SPOP, speckle-type POZ protein; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor; VEGFR, VEGF receptor; GM-CSF, granulocyte–macrophage colony-stimulating factor; EPH, ephrin; NF, nuclear factor; SHC, src homology 2 domain-containing transforming protein C; EPHA, ephrin receptor A; ERBB4, erb-b2 receptor tyrosine kinase 4; PI3K, phosphatidylinositol-4, 5-bisphosphate 3-kinase; GPVI, glycoprotein VI.