Table 1.
Reported cases of non-functional parathyroid carcinoma
| References |
Basic Information |
Serum hormone levels |
Cancer basics |
Adjuvant therapy |
Prognosis |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Author | Publication date | Sex | Age | Ca (mg/dl) | PTH (pg/ml) | Clinical presentation | Tum or size (cm) | Local invasion | Surgery | Radiation therapy | Chemotherapy | Local recurrence | Metastasis | Survival | |
| Current study | 2014 | F | 45 | 9.3 | 40 | Neck mass | 1.1×1.0×1.0 | Yes | en bloc resection, total thyroidectomy, cervical lymph node dissection | No | No | No | No | Alive at 2 months | |
| Piciu D[4] | 2013 | F | 51 | 9.1 | 54 | Neck mass | 2.5 | No | en bloc resection, total thyroidectomy, cervical lymph node dissection | No | No | No | No | Alive at 15 months | |
| Zeljko Kotromanovi[5] | 2012 | M | 65 | 9.1 | 47.2 | Neck mass | 8.0×4.0 | Yes | R selective lymphadenectomy | No | No | Yes | Yes | Alive at 54 months | |
| Yitong Xu[6] | 2012 | F | 54 | 9.7 | NR | Neck mass | 3.5×3.0 | NR | R thyroid lobectomy, neck dissection | No | No | Yes | NR | NR | |
| Chao Chen[7] | 2011 | M | 44 | 10.1 | NR | Neck mass, hoarseness | 1.0×1.0×0.8 | Yes | R thyroid lobectomy + neck dissection | No | No | No | Yes | Alive at 72 months | |
| Krvavica A[8] | 2011 | M | 60 | Normal | Normal | Neck mass | 6.0×6.0×10 | Yes | total thyroidectomy, en bloc resection, L thyroid lobectomy, cervical lymph node dissection | No | No | No | No | Dead at 36 months | |
| Benjamin J [2] | 2009 | M | 59 | 10.1 | 20 | Dysphagia, hoarseness, neck mass | 9.5×6.5×6.5 | Yes | en bloc resection mass | Yes | No | No | No | Alive at 7 months | |
| W.C.Gao[9] | 2009 | M | 47 | 10.5 | 42.8 | Neck mass, hoarseness | 4.0, 2.5 | Yes | L thyroid lobectomy + neck dissection (levels II-VI) | No | No | No | No | Alive at 8 months | |
| Mazeh H[10] | 2008 | F | 44 | 10.1 | NR | Neck mass | 1.5 | NR | L thyroid lobectomy | No | No | No | No | Alive at 60 months | |
| Grodski[11] | 2008 | M | 46 | 9.4 | NR | Neck mass | 12 | No | total thyroidectomy, neck exploration | No | No | No | No | NR | |
| Fernandez-Ranvier [12] | 2007 | F | 67 | 9.1 | 19 | Multinodular goiter | 4.5×2.0×0.8 | Yes | total thyroidectomy | Yes | No | Yes | Yes | Alive at 31 months | |
| Ashkenazi D[13] | 2006 | F | 54 | 10-10.8 | 62(with parathyroid adenoma) | mild osteopenia, nonspecific renal pain | NR | No | L hemithyroidectomy | No | No | No | No | Alive at 12 months | |
| Kirkby-Bott [14] | 2005 | M | 66 | Normal | NR | Neck mass, tracheal obstruction | NR | Yes | neck exploration, incomplete exc | Yes | No | Yes | Yes | Dead at 98 months | |
| Eurelings M[15] | 2002 | F | 45 | Normal | NR | Dysphagia, hoarseness | NR | Yes | hemithyroidectomy | Yes | Yes | No | Yes | Dead at 45 months | |
| Yamashita[16] | 1992 | F | 56 | 9.2 | Normal | Sore throat, neck mass | Diameter: 3.0 | Yes | mass+ thyroid lobe | Yes | No | No | No | Alive at 10 months | |
| Klink[17] | 1991 | M | 39 | 9.2 | 0.4 (0.3–2.9) | Neck mass, hoarseness, nephrolithiasis | 7.5×5.5×5.0 | Yes | en bloc resection | No | No | No | No | Alive at 4 months | |
| Collins[18] | 1986 | M | 65 | 9.4 | NR | MNG, dyspnea, dysphagia | 11.0×5.0×5.0 | Yes | L thyroid lobectomy | No | No | No | No | Alive at 24 months | |
| Murphy[19] | 1986 | M | 51 | Normal | Normal | Hoarseness, dyspnea, mediast. Mass | Extensive | Yes | incomplete resection | Yes | Yes | Yes | No | Alive at 11 months | |
| Baba, H[20] | 1986 | F | 64 | 9.3 | 200 (NL<300pg/ml) | Neck mass | 5.0×4.0 | Yes | en bloc resection* | NR | NR | Yes | NR | NR | |
| Merlano[21] | 1985 | M | 59 | Normal | Normal | Neck mass, VCP, dysphagia, axillary LN | 8.0×6.0×4.0 | Yes | biopsies | Yes (Preoperative R+R) | No | Yes | Yes | Alive at 48 months | |
| Yamashita[22] | 1984 | F | 69 | 9.3 | NR | Neck mass | 5.0×4.0×3.0 | Yes | L thyroid lobectomy | Yes | No | No | No | Alive at 20 months | |
| Hickey et al[23-25] | 1982-1983 | M | 27 | 9.2-9.8 | NR | Neck mass | 5.5 | Yes | simple excision | Yes | Yes | Yes | Yes | Dead at 28 months | |
| M | 49 | NR | NR | Neck mass | NR | Yes | No | No | Yes | Yes | Yes | Alive at 9 months | |||
| M | 59 | 9.5 | NR | Neck mass | 2.5 | Yes | total thyroidectomy, L radical neck dissection | No | Yes | Yes | Yes | Dead at 20 months | |||
| Chahinian[26] | 1981 | F | 69 | Normal | Normal | Neck mass, pleural effusion | 2.0×2.0 | Yes | nodule excision | No | Yes | Yes | Yes | Alive at 96 months | |
| Dhom G[27] | 1980 | M | 38 | Normal | NR | Neck mass | 2.5×1.5 | Yes | radical thyroidectomy | No | No | NR | NR | NR | |
| Altenahr [28] | 1973 | M | 50 | Normal | NR | Neck mass | NR | Yes | L thyroid lobectomy | Yes | No | Yes | Yes | Alive at 84 months | |
| Pachter MR[29] | 1963 | F | 50 | Normal | NR | Chest pain | Diffuse | Yes | partial excision | No | No | Yes | Yes | Alive at 60 months | |
| Sieracki[30] | 1960 | F | 43 | 9.1 | NR | Neck mass, pain, dysphagk VCP | 5.0×4.0 | Yes | subtotal resection | Yes | No | Suspicious | Suspicious | Alive at 36 months | |
| McQuillan [31] | 1938 | F | 53 | Normal | NR | Neck mass | Golf ball | Yes | R thyroid lobectomy | Yes | No | Yes | No | Alive at 28 months | |
| Armstrong [32] | 1938 | F | 71 | 11.9 | NR | Neck mass | 11.0×11.0×4.0 | Yes | en bloc resection | No | No | No | No | Alive at 2 months | |
| Guy [33] | 1929 | F | 29 | 8 | NR | Neck mass, dysphagia, pain | 8.0×6.0×4.0 | Yes | simple excision | Yes | No | Yes | Yes | Alive at 28 months | |
NR: not reported. *: L thyroid lobectomy and neck dissection was performed in 1981 because of functional parathyroid carcinoma.