Figure 4.
CAF-CM with exosomes containing hMAPK miR221/222 are involved in ER repression.(A) Western blot data showing effect of exosome depleted CAF conditioned media on pERK and ER of MCF/ltE2- cells treated with different CAF conditioned media. GAPDH used as loading control. (B) Cancer associated fibroblast-derived exosomes uptake by MCF-7/lt E2- breast cancer cells. (A) HMF exosomes. (B) CAF19 exosomes. (C) CAF21 exosomes. (D). CAF23 exosomes. (C). A volcano plot showing miRNAs that are differentially expressed in CAF23BAS vs. CAF19LA conditioned media.