Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A simplified depiction of the MAPK pathway. Binding to the PDGF or EGF receptor results in activation of the RAS/RAF pathway and subsequent cell proliferation and differentiation. Blockade of the BRAF kinase with vemurafenib halts this process seen in the progression of many cancers.
