Table 4.
Pathway analysis of top CpG probes (meta P < 1.00e-04) derived from the EWAS meta-analysis of prenatal maternal stress exposure in neonates (ntotal = 1,740).
|
Pathway tool |
Output |
|||
|---|---|---|---|---|
| PANTHER GO-slim Molecular Function | Expected ngenes | Observed ngenes | Fold enrichment | Pathway enrichment P |
| Methyltransferase activity |
0.26 |
4 |
>5 |
0.002$ |
| DAVID | Count | Coverage | Enrichment score | Pathway enrichment P |
| Methyltransferase activity |
5 |
1.1% |
2.46 |
0.06* |
| GeneMANIA | Coverage | Pathway enrichment P | ||
| Methyltransferase activity | 7/87 | 4.76e-04* | ||
$
PANTHER reports the Bonferroni method
*
DAVID and GeneMANIA report the Benjamini-Hochberg (false-discovery rate, FDR) method.