Table 1.
Partial list of molecules differentially expressed in OKF6/TERT1 cells chronically treated with chewing tobacco compared to untreated cells.
| Gene symbol | Description | Tobacco treated/untreated (fold change) | Associated biological processes |
|---|---|---|---|
| ERH | Enhancer of rudimentary homolog | 7.1 | Cell cycle progression53 |
| ERGIC3 | ERGIC and golgi 3 | 3.8 | Regulation of cell growth54 |
| MKI67 | Marker of proliferation Ki-67 | 2.8 | Cell cycle control55 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 2.7 | Cell growth and/or maintenance56 |
| SCD | Stearoyl-CoA desaturase | 2.6 | Fatty acid metabolism18 |
| CCAR1 | cell division cycle and apoptosis regulator 1 | 2.6 | Regulation of cell proliferation57 |
| FLNB | Filamin B, β | 2.0 | Cell proliferation38 |
| EPS8 | Epidermal growth factor receptor pathway substrate 8 | 2.0 | Cell communication; Signal transduction58 |
| S100A14 | S100 calcium binding protein A14 | 1.9 | Chemotaxis59 |
| HSPA5 | Heat shock 70kDa protein 5 | 1.6 | Regulation of apoptotic process60 |
| ENO1 | Enolase 1 | 0.5 | Regulation of cell growth61 |
| TAGLN2 | Transgelin 2 | 0.5 | Tumor suppressor62 |
| PLIN3 | Perilipin 3 | 0.5 | Transport63 |
| KIF13A | Kinesin family member 13A | 0.5 | Cell growth and/or maintenance64 |
| CDH13 | Cadherin 13 | 0.4 | Regulation of cell proliferation65 |
| PKM | pyruvate kinase, muscle | 0.4 | programmed cell death66 |
| S100A11 | S100 calcium binding protein A11 | 0.3 | Tumor suppressor67 |
| TENM2 | Teneurin transmembrane protein 2 | 0.3 | Cell adhesion68 |
| PDCD4 | Programmed cell death 4 | 0.3 | Tumor suppressor40 |
| GSN | Gelsolin | 0.3 | Apoptotic process69 |