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. 2015 Sep 29;16(11):1626–1640. doi: 10.1080/15384047.2015.1095396

Figure 8.

Figure 8.

Enhanced invasion of CD151-silenced cells depends on α3β1 integrin. CD151sh3 cell spheroids were embedded in 3D collagen in the absence (A&B) or presence (C&D) of 10 µg/ml A3-IIF5 anti-α3 integrin function blocking antibody, and photographed on Day 1 and Day 4. (E-H) Parental cell spheroids were embedded in collagen with or without A3-IIF5 antibody, as for the CD151sh3 spheroids in (A-D). (I) Quantification of spheroid size on Day 4 plotted as fold change from Day 1. The untreated CD151sh3 cell spheroids were significantly larger than either parental cell spheroids or antibody-treated CD151sh3 cell spheroids, *P<0 .0001, ANOVA with Tukey post-tests.