Table 2.

Multivariate Cox regression model analysis for the MMSS (n = 286).

Variable	Level	Reference	HR (95% CI)	P-value
Patient cohort	Italy	Germany	0.81 (0.51–1.30)	0.385
Age*			1.03 (1.01–1.06)	0.001
Gender	Male	Female	0.87 (0.48–1.58)	0.645
Location	Non-OPSSC	OPSCC	0.72 (0.45–1.14)	0.162
Tumor size	T3-4	T1-2	3.30 (1.73–6.29)	3e-04
Lymph nodes	N+	N0	2.02 (1.12–3.64)	0.020
Distant metastasis	M+	M0	5.91 (2.64–13.22)	<1e-04
Staging	S3-4	S1-2	0.38 (0.14–1.01)	0.052
Grading	G3	G1-2	1.30 (0.86–1.95)	0.209
First therapy	Surgery	No Surgery	0.64 (0.40–1.01)	0.055
HPV16 status	DNA+/RNA+	DNA− or DNA+/RNA−	0.71 (0.26–1.92)	0.502
Alcohol status	Former or current	Never	1.80 (0.97–3.34)	0.062
Smoking status	Former or current	Never	1.34 (0.73–2.46)	0.342
MMSS	MMSS_p	MMSS_g	2.15 (1.36–3.41)	0.001

HR, hazard ratio; CI, confidence interval.

^*continuously