Figure 6.

BDNF rs6265 methylation and gene regulation. a: Scatterplots of the correlations between rs6265 methylation (T scores) and Total BDNF in serum measured with ELISA (N = 39: 23 ValVal and 16 ValMet): increased methylation in PBMCs is correlated with increased expression in ValVal subjects and with attenuated expression in ValMet heterozygotes. b: Scatterplot of the correlation between methylation of rs6265 region in PBMCs and in prefrontal cortex in a group of transgenic mice carrying the human mutation (N = 17). c: Bargraph (mean + s.e.m.) of the effects of rs6265 genotype on binding of hypoxia-related proteins to the rs6265 region (N = 20: 11 ValVal and 9 ValMet). See text and Supplemental file 1 for statistics.