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. 2016 Jan 19;11(1):24–35. doi: 10.1080/15592294.2015.1127479

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted..

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Figure 4. — Cases of allelic-flipping of DNA methylation between individuals are found both in known imprinted gene clusters as well as regions not previously confirmed as being imprinted. The heatmaps show allele signal intensities for genomic DNA (G), MSRE-digested DNA (D) and fully unmethylated, MSRE-digested DNA (U) in all tissues. A and B denote the 2 alleles of the SNP and brightness represents the quantile normalized signal intensity, with the scale displayed below the heatmap. (A)-(C) Three probes in the vicinity of the known imprinted cluster on chromosome 15q11.2 show variable ASM and allelic-flipping in cerebellum [(A) rs940596, (B) rs11633486, (C) rs11854691]. (D) Allelic-flipping of DNA methylation across all tissues is observed in the vicinity of WRB (rs2244352), which has not been reported as imprinted previously.