Table 7.
Enrichment in intermediate methylation (IM) near ASM regions.
| IM rate | O/E | P | |
|---|---|---|---|
| Bloodd | 5.88% | 0.98 | 0.576 |
| Cerebellumd | 11.49% | 1.75 | 0.059 |
| BA9d | 13.29% | 1.45 | 0.065 |
| Cross-tissue | 8.11% | 0.87 | 0.741 |
| Tissue-specific | 8.00% | 0.85 | 0.701 |
| Variable | 38.46% | 4.10 | 9.56 × 10−11 |
| Variable (BA9)d | 37.50% | 4.09 | 8.86 × 10−9 |
| Variable (cerebellum)d | 16.95% | 2.58 | 0.005 |
| Variable (blood)d | 34.48% | 5.77 | 6.82 × 10−11 |
c
IM is defined as an average methylation between 0.4 and 0.6, enrichment P values are based on a hypergeometric test based on the background distribution of IM.
d
We used tissue-specific background distributions for ASM types based on single tissues.