Table 3.
Longitudinal changes in cerebral metabolite ratio parameters
| Parameter mean (SD) | Day 0 (n = 11) | Day 14 (n = 11) | Change over study period | p-value for change over study period |
|---|---|---|---|---|
| TARQUIN | ||||
| Frontal grey matter | ||||
| NAA/Cr | 1.13 (0.21) | 1.16 (0.20) | 0.03 (0.15) | 0.88 |
| Cho/Cr | 0.19 (0.033) | 0.20 (0.025) | 0.01 (0.025) | 0.42 |
| mI/Cr | 0.75 (0.17) | 0.68 (0.19) | −0.07 (0.14) | 0.17 |
| Frontal white matter | ||||
| NAA/Cr | 1.25 (0.26) | 1.25 (0.24) | 0.00 (0.27) | 0.83 |
| Cho/Cr | 0.28 (0.045) | 0.30 (0.068) | 0.02 (0.076) | 0.22 |
| mI/Cr | 0.91 (0.28) | 0.97 (0.23) | 0.06 (0.27) | 0.23 |
| Right basal ganglia | ||||
| NAA/Cr | 1.41 (0.24) | 1.51 (0.21) | 0.10 (0.14) | 0.18 |
| Cho/Cr | 0.28 (0.033) | 0.28 (0.034) | 0.00 (0.060) | 0.91 |
| mI/Cr | 0.76 (0.27) | 0.71 (0.28) | −0.05 (0.35) | 0.61 |
| jMRUI16 | ||||
| Frontal grey matter | ||||
| NAA/Cr | 1.75 (0.19) | 1.72 (0.20) | −0.02 (0.21) | 0.74 |
| Cho/Cr | 0.66 (0.10) | 0.67 (0.47) | 0.02 (0.14) | 0.73 |
| mI/Cr | 0.64 (0.33) | 0.65 (0.01) | 0.01 (0.63) | 0.96 |
| Frontal white matter | ||||
| NAA/Cr | 1.76 (0.20) | 1.77 (0.19) | 0.01 (0.19) | 0.99 |
| Cho/Cr | 1.05 (0.22) | 1.05 (0.18) | 0.00 (0.23) | 0.98 |
| mI/Cr | 1.09 (0.65) | 1.25 (0.55) | 0.17 (0.65) | 0.41 |
| Right basal ganglia | ||||
| NAA/Cr | 1.82 (0.39) | 2.09 (0.31) | 0.27 (0.61) | 0.18 |
| Cho/Cr | 0.78 (0.12) | 0.92 (0.24) | 0.14 (0.23) | 0.07 |
| mI/Cr | 0.69 (0.50) | 0.93 (0.48) | 0.24 (0.60) | 0.17 |
Cho, choline; Cr, creatine; jMRUI, java-based version of the MR user interface; mI, myo-inositol; NAA, N-acetylaspartate; SD, standard deviation; TARQUIN, totally automatic robust quantitation in nuclear MR.