. Author manuscript; available in PMC: 2017 Mar 1.

Published in final edited form as: Bioorg Med Chem. 2016 Jan 6;24(5):938–956. doi: 10.1016/j.bmc.2016.01.007

Table 1.

Cytotoxicity data for the amino-based combretastatin, dihydronaphthalene, and benzosuberene analogues against human cancer cell lines [SK-OV-3 (ovarian), NCI-H460 (lung), and DU-145 (prostate)]

Compound	GI₅₀ (nM) SRB Assay^a

	SK-OV-3	NCI-H460	DU-145
CA1^b	38.4±24.2	15.3±15.8	32.6±17.3
CA4^c	5.06±0.145	5.00±0.359	6.02±0.661
3' CA4-amine^d	4.45±0.870	4.49±0.894	3.30±0.281
3' CA4-L- serinamide^d	9.02±4.81	24.1±2.00	16.4±7.29
AVE8062^d	3.96±0.912	3.87±0.297	3.34±0.261
7^e	26.6±22.6	40.1±17.1	33.1±21.4
8^f	23.5±23.4	35.9±21.8	39.1±26.5
9	7.35±3.50	26.3±16.1	28.5±23.2
10^f	22.8±15.2	124±116	205±241
13^e	39.5±21.1	33.3±19.0	34.7±8.27
14	32.3±6.38	53.2±5.23	43.6±2.43
15^e	51.6±6.88	31.7±4.87	48.4±3.36
16	48.5±8.53	29.2±5.67	44.7±3.53
17	2290±1170	2240±1450	4550±2700
18	427±111 (D)	418±137 (D)	630±306 (D)
	426±94.1 (W)	380±60.2 (W)	674±255 (W)
22	25900±2550	24400±4420	33600±2600
23	>86600	>86600	>86600
24	39300±13500 (D)	>68500 (D)	>64700 (D)
	>56400 (W)	>96600 (W)	>90400 (W)
32^g	0.308±0.402	0.290±0.126	0.111±0.114
33^h	0.137±0.0596	1.85±1.87	2.26±1.58
36	13700±9700	31100±9940	40600±32300
37	44900±4100	45900±1790	>81300
38	11600±10200	18600±7670	26000±15700
39	47000±21400	53800±864	69400±31300
42ⁱ	13.8±7.54	36.5±0.899	50.1±4.80
43	195±31.9	566±38.2	507±188
44	48.5±32.5	42.0±3.72	58.5±12.0
45	203±29.4	567±56.6	773±302

Average of n ≥ 3 independent determinations.

Data from ref⁷⁴, see ref. ¹⁴ for additional data.

For additional data, see ref. ¹⁴

For additional data, see ref. ^15,36,37,53

For additional data, see ref. ¹⁵

For additional data, see ref. ¹⁶

For additional data, see ref. ^42,43

For additional data, see ref.^46,47

ⁱ

For additional data, see ref.⁴⁷

D = compound dissolved in DMSO. W = compound dissolved in water