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. 2015 Oct 28;6:8672. doi: 10.1038/ncomms9672

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(a) Clathrin is recruited at Dab2-mCherry-positive RGD clusters. (b) Pearson's correlation analysis of clathrin and Dab2, integrin-beta3 and RGD clusters. Clathrin colocalizes with Dab2, integrin-beta3 and RGD clusters when cells adhere on RGD membranes. (c,d) Western blots to confirm the knockdown of Dab2 and Numb, respectively. Full blots are available in Supplementary Fig. 11. (e) Single knockdown of Dab2 or Numb does not abolish the clathrin recruitment at RGD-integrin clusters. Dual knockdown of both Dab2 and Numb effectively removes clathrin from RGD-integrin clusters. Also see Supplementary Fig. 8. All data are the mean of three independent experiments (n>20 in each condition). Error bars represent s.d., and all samples represent biological replicates. Detailed statistical results are available in Supplementary Table 1. Scale bar, 10 μm.