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. 2016 Mar 23;5:e13841. doi: 10.7554/eLife.13841

Author response image 2. EPS15 depletion affects late endosomal maturation.

Author response image 2.

(A) Co-depletion of SPOPL an EPS15 has an additive effect on influenza A virus infection. (B) EPS15 depletion stabilizes ESCRT components HRS, STAM and TSG101. (C) EPS15 depletion affects LDL uptake in cells resulting in an accumulation of LDL in enlarged vacuoles (upper panel). Late endosomes, visualized by life-cell microscopy of GFP-RAB7, are enlarged in cells depleted of EPS15 (lower panel).

DOI: http://dx.doi.org/10.7554/eLife.13841.016