Table 2. Outcome measures reported in the studies of adenoid cystic carcinoma included in the review.
| Author | Year | n | Site | PNI (%) | OS | DFS | DM | LRR | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Period (y) | % PNI + /%PNI− | p Value | Period (y) | % PNI + /%PNI− | p Value | Period (y) | % PNI + /%PNI− | p Value | Period (y) | % PNI + /%PNI− | p Value | |||||
| Vrielinck et al63 | 1988 | 37 | Mix | 19 (51) | 10 | 37/94 | < 0.001 | 50/0 | 0.0007 | 57.9/22.2 | n/a | |||||
| Garden et al | 1995 | 198 | Mix | 136 (69) | 10 | 45/73 | 0.002 | 60/39 | < 0.001 | 10 | 89/81 | 0.28 | ||||
| Huang et al | 1997 | 91 | Mix | 57 (63) | 10 | 29/60 | < 0.01 | |||||||||
| Fordice et al | 1999 | 160 | Mix | 79 (49) | 0.04a | |||||||||||
| Kim et al | 1999 | 19 | Paranasal | 5 (29) | 10 | 20/55 | 0.01 | |||||||||
| Chummun et al | 2001 | 45 | Mix | 23 (51) | 5 | 68/93.5 | < 0.05 | |||||||||
| Khan et al | 2001 | 68 | Mix | 3 (32) | NS | |||||||||||
| Kokemueller et al | 2004 | 74 | Mix | 32 (43) | 10 | 77/23 | < 0.001 | |||||||||
| Mendenhall et al | 2004 | 101 | Mix | 32 (32) | 0.0011 | 5 | 61/92 | 0.0015 | 5 | 0.0055 | ||||||
| Rapidis et al | 2005 | 22 | Major and paranasal | 18 (81) | 0.0044 | NS | ||||||||||
| Chen et al | 2006 | 140 | Mix | 82 (59) | 10 | 87/69 | 0.04 | |||||||||
| Agarwal et al | 2008 | 76 | Minor–oral | 24 (32) | 5 | 23/80 | 0.053 | 5 | 29/97 | 0.003 | ||||||
| Gomez et al | 2008 | 59 | Mix | 42 (71) | NS | NS | NS | NS | ||||||||
| Amit et al | 2014 | 495 | Mix | 239 (48) | 5 | 4.8b | 0.0006 | |||||||||
Abbreviations: DFS, disease free survival; DM, distant metastasis; LRR, loco-regional recurrence; n/a, not available; NS, not significant; OS, overall survival; PNI, perineural invasion.
Note: Mix—major salivary glands and Minor salivary glands (oral cavity and paranasal sinuses).
a
Only named nerves.
b
Hazard ratio of intraneural invasion—cancer cells in endoneurium.