Table 1.
Reproducibility of anti-3-[18F]FACBC uptake in background structures and malignant lesions on follow-up PET-CT in prostate carcinoma: an exploratory analysis
| SUVmean of background structures at early (4 min) imaging when comparing original to follow-up scans | ||||||
|---|---|---|---|---|---|---|
| Organ | Scan 1, mean (SD) | Scan 2, mean (SD) | p value (t test or Wilcoxon) | Average absolute difference at 4 min (SD) | % Mean difference at 4 min (SD) | ICC (95 % CI) |
| Aorta (blood pool) | 1.41 (0.15) | 1.44 (0.19) | 0.47 | 0.1 (0.1) | 14.2 (11.1) | 0.4 (−0.1–0.7) |
| Liver | 7.54 (1.16) | 7.85 (1.91) | 0.41 | 1.2 (0.8) | 14.9 (9.2) | 0.6 (0.2–0.9) |
| Marrow | 3.06 (0.58) | 3.26 (0.71) | 0.04 | 0.3 (0.2) | 10.7 (6.5) | 0.8 (0.6–0.9) |
| Pancreas | 13.16 (3.92) | 12.77 (3.33) | 0.38 | 1.0 (1.2) | 7.2 (8.1) | 0.9 (0.8–1.0) |
| Muscle | 1.13 (0.38) | 1.25 (0.44) | 0.12 | 0.2 (0.2) | 18.2 (17.8) | 0.8 (0.4–0.9) |
| Spleen | 2.96 (0.44) | 3.11 (0.35) | 0.12 | 0.3 (0.2) | 10.6 (7.3) | 0.6 (0.1–0.8) |
| SUVmean of background structures at delayed (17 min) imaging when comparing original to follow-up scans | ||||||
| Organ | Scan 1, mean (SD) | Scan 2, mean (SD) | p value (t test or Wilcoxon) | Average absolute difference at 17 min (SD) | % Mean difference at 17 min (SD) | ICC (95 % CI) |
| Aorta (blood pool) | 1.12 (0.40) | 1.12 (0.36) | 0.91 | 0.1 (0.2) | 13.3 (10.1) | 0.7 (0.2–0.9) |
| Liver | 7.18 (1.08) | 7.29 (1.88) | 0.75 | 0.9 (0.7) | 12.5 (7.1) | 0.7 (0.3–0.9) |
| Marrow | 2.66 (0.65) | 2.66 (0.56) | 1.00 | 0.2 (0.1) | 6.9 (6.6) | 0.9 (0.8–1.0) |
| Pancreas | 8.72 (3.75) | 8.28 (2.60) | 0.33 | 1.1 (1.1) | 13.8 (13.4) | 0.9 (0.7–1.0) |
| Muscle | 1.44 (0.47) | 1.53 (0.61) | 0.32 | 0.2 (0.3) | 13.8 (13.3) | 0.8 (0.5–0.9) |
| Spleen | 2.05 (0.51) | 2.18 (0.33) | 0.20 | 0.3 (0.2) | 14.9 (11.0) | 0.7 (0.3–0.9) |