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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: J Pharm Sci. 2016 Mar 15;105(5):1603–1613. doi: 10.1016/j.xphs.2016.02.009

Figure 4. Toxin-neutralizing titers in sera of mice immunized with RB and RC derivatives.

Figure 4

Groups of mice (n = 8 mice/group) were immunized with 5μg of RiVax, RB or RC adsorbed to Alhydrogel. Serum samples were collected from the mice following the second (A) and third (B) immunizations and assessed for toxin-neutralzing activity in a Vero cell assay. (C) Groups of animals were then challenged with 10xLD50 ricin, as described in the Materials and Methods. An unpaired t-test comparing each variant to RiVax was used to compute statistical significance.* p < 0.05, ** p < 0.01.