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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: J Mol Cell Cardiol. 2016 Mar 3;93:98–105. doi: 10.1016/j.yjmcc.2016.02.020

Fig. 2.

Fig. 2

Raf1L613V/+ mutation resulted in high cardiac output due to low afterload. A. Representative pressure-volume loops studied by left ventricular catheterization of female mice to acquire preload-independent parameters. Loop series were obtained by inferior vena cava compression following a limited right thoracotomy. See Table 3 for analysis. Red lines indicate end-systolic and end-diastolic pressure-volume relationships (ESPVR and EDPVR, respectively). B. Quantification of cardiac output, arterial elastance, end-systolic elastance (ESPVR slope) and preload recruitable stroke work (PRSW). n = 6–8 per cohort. †p-Value vs. WT; §p-value vs. RSK3–/–.