Table 1.

Echocardiography: data – 4 week old female mice.

		WT	RSK3–/–	RAF1L613V/+			RSK3–/–;RAF1L613V/+		ANOVA
n		22	15	16			8
LVPW;d	mm	0.57 ± 0.01	0.61 ± 0.02	0.68 ± 0.02	† † †		0.58 ± 0.03	*	‡ ‡ ‡
LVPW;s	mm	0.86 ± 0.02	0.92 ± 0.03	1.03 ± 0.04	† † †		0.92 ± 0.04		‡ ‡
LVAW;d	mm	0.65 ± 0.02	0.67 ± 0.02	0.70 ± 0.03			0.63 ± 0.04
LVAW;s	mm	1.00 ± 0.04	1.02 ± 0.05	1.16 ± 0.05			1.00 ± 0.07
LVID;d	mm	3.48 ± 0.05	3.59 ± 0.05	3.81 ± 0.06	† † †		3.77 ± 0.11	†	‡ ‡ ‡
LVID;s	mm	2.40 ± 0.07	2.46 ± 0.09	2.49 ± 0.08			2.56 ± 0.14
ID:(PW + AW)		2.90 ± 0.10	2.82 ± 0.10	2.80 ± 0.09			3.14 ± 0.14
LV Vol;d	μL	51 ± 2	54 ± 2	63 ± 2	† † †	§	61 ± 4	†	‡ ‡ ‡
LV Vol;s	μL	21 ± 2	22 ± 2	23 ± 2			24 ± 3
EF	%	48 ± 4	60 ± 2	64 ± 2	† †		61 ± 3		‡ ‡
FS	%	31 ± 1	32 ± 2	35 ± 1			32±2
LV mass	mg	52 ± 2	59 ± 2	72 ± 3	† † †	§ §	60 ± 5	a	‡ ‡ ‡
BW	g	13.1 ± 0.4	14.0 ± 0.3	13.5 ± 0.3			13.5 ± 0.6
LV mass/BW	mg/g	4.0 ± 0.1	4.2 ± 0.1	5.3 ± 0.2	† † †	§ § §	4.4 ± 0.3	*	‡ ‡ ‡

LVPW, left ventricular posterior wall thickness; LVAW, left ventricular anterior wall thickness; LVID, left ventricular internal diameter; d, diastole; s, systole; ID:(PW + AW) = LVID;d / (LVPW;d + LVAW;d); Vol, volume; EF, ejection fraction; FS, fractional shortening; BW, body weight. All data are mean ± s.e.m.

^†p-Value vs. WT.

^§p-Value vs. RSK3^–/–.

^*p-Value vs. Raf1^L613V/+.

^ap = 0.07.