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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Neurosci Res. 2015 Oct 28;106:47–54. doi: 10.1016/j.neures.2015.10.007

Fig. 2.

Fig. 2

The time intervals of changes in withdrawal latency responses to heat and cold stimuli (top and middle panels) and mechanical threshold (bottom panels) on the control and treated sides of foot induced by 2,5-hexanedione (2,5-HD) intoxication in ZDF rats compared to lean control (LC) rats. Withdrawal latency responses to heat and cold stimuli and mechanical threshold showed significant decreases in the control value of ZDF rats compared to LC rats. Mechanical tolerance thresholds and withdrawal latencies to heat and cold stimuli were significantly decreased on both sides of the foot at 3, 6, and 14 days after 2,5-HD treatments in ZDF and LC rats. Values are mean ± SEM (n = 5-6/group). *: P < 0.05, compared with before treatment; #: P < 0.05, compared with LC rats.