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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: J Mol Cell Cardiol. 2015 Nov 20;93:143–148. doi: 10.1016/j.yjmcc.2015.11.016

Figure 1.

Figure 1

Damage associated molecular patterns (DAMPs) are derived from dying cells that release their cytosolic content following myocardial injury, or from degradation of the extracellular matrix, as well as by immune cells that become activated following tissue injury. (Key: ATP = adenosine triphosphate, HSP = heat shock protein; HMGB1 = high mobility box group 1 protein, IL-1α - interleukin-1α; IL-1R– interleukin receptor NALP = NACHT, LRR and PYD domains-containing protein 3 (cryopyrin); RAGE = receptor for advanced glycation end products, TLR = Toll-like receptor) (Reproduced with permission Mann DL. In Blankesteijn WM and Altara R, eds. Inflammation in Heart Failure, Elsevier/Associated Press; 2015. p. 191–201)