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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: J Mol Cell Cardiol. 2015 Dec 1;93:73–83. doi: 10.1016/j.yjmcc.2015.11.020

Figure 2. Agent-based modeling of infarct wound healing.

Figure 2

Rouillard and Holmes used an agent-based framework to capture fibroblast proliferation, orientation, migration, and collagen remodeling in response to mechanical, chemical, and structural cues. During the healing time course, high chemokine levels in the wound lead to fibroblast infiltration and collagen accumulation, and the strainpattern (biaxial vs. uniaxial) determined fibroblast and collagen orientations (random vs. aligned, respectively). Figure is adapted with permission by the Journal of Physiology from Rouillard and Holmes 2012 [62].