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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: J Mol Cell Cardiol. 2015 Dec 1;93:73–83. doi: 10.1016/j.yjmcc.2015.11.020

Figure 3. Fibroblast Signaling Network.

Figure 3

(A) Schematic of signaling network incorporating integrin, TGFβ, and FGF pathways. The red line indicates the time-dependent ERK regulation included in model 4 (B) Comparison of the experimental levels of ERK phosphorylation with TGFβ or FGF treatment with the model prediction demonstrates that including ERK regulation improved the model prediction. Figures adapted with permission by Cellular and Molecular Bioengineering from Schroer et al 2014 [84].