Table 3.

Paired t-tests of mean percent of days used by subgroup across assessment points.

Assessment point comparison	Mean difference	S.E.	p-valuea	95% CI
Low Use Responders (n=109)
ETx - Intake	−0.16	0.02	<0.01	(−0.21, −0.11)
3 Months – ETx	0.01	0.02	1.00	(0.03, 0.06)
6 Months – 3 Months	−0.02	0.01	1.00	(−0.06, 0.02)
9 Months – 6 Months	0.01	0.01	1.00	(−0.02, 0.03)
High Use Responders (n=45)
ETx – Intake	−0.63	0.05	<0.01	(−0.77, −0.48)
3 Months – ETx	−0.01	0.04	1.00	(−0.14, 0.12)
6 Months – 3 Months	0.11	0.04	0.10	(−0.01, 0.23)
9 Months – 6 Months	−0.02	0.05	1.00	(−0.15, 0.12)
Relapsers (n=25)
ETx – Intake	−0.28	0.08	0.02	(−0.51, −0.04)
3 Months – ETx	0.28	0.08	0.02	(0.03, 0.53)
6 Months – 3 Months	0.31	0.06	<0.01	(0.12, 0.51)
9 Months – 6 Months	0.11	0.04	0.11	(−0.01, 0.02)
Non-Responders (n=15)
ETx – Intake	−0.03	0.08	1.00	(−0.28, 0.23)
3 Months – ETx	0.09	0.08	1.00	(−0.19, 0.37)
6 Months – 3 Months	−0.04	0.09	1.00	(−0.34, 0.25)
9 Months – 6 Months	0.05	0.09	1.00	(−0.24, 0.34)

^ap-values are Bonferroni adjusted for multiple comparisons