Figure 4.
Thiamine deficiency accelerates deposition of thioflavin S–positive amyloid plaque. Mice were made thiamine deficient (TD) for 10 days, and the number of thioflavin S–positive plaques were determined throughout the brain.56 The graph shows the percent area occupied by plaques quantified from the cortex, hippocampus, and thalamus. Data represent the means ± SEM (control, n = 9; TD, n = 10) from 2–3 independent experiments.
