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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2016 Feb 18;1862(6):1122–1136. doi: 10.1016/j.bbadis.2016.02.008

Fig. 12. Schematic diagram of signaling role of PAK2 in pancreatic acinar cells.

Fig. 12

In rat pancreatic acinar cells CCK-induced PAK2 activation is mediated by activation of CDC42/Rac1, Src and PKC [8]. Activation of PAK2 is needed to stimulate several signaling kinases including MAPKs (p42/44, JNK), FAKs (p125FAK, PYK2) and scaffolding proteins (paxillin, p130CAS) that are important in mediating numerous cellular functions. Activation of PAK2 has a unique dual role in altering activity of the PI3K-Akt pathway being required for stimulation of p85, but also mediating inhibition of AKT activity via dephosphorylation of Akt, which a previous study proposes requires activation of phosphatases in a PKC-dependent manner [33].