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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2016 Feb 18;1862(6):1122–1136. doi: 10.1016/j.bbadis.2016.02.008

Fig. 8. Effect of inhibition of PAK2 on CCK-mediated apoptosis in pancreatic acini.

Fig. 8

Freshly isolated rat pancreatic acini were pre-incubated with either 40 μM IPA-3 or Pir 3,5 for 3 hours. Caspase (caspase 3, 8, 9) activities were measured as described in Materials and Methods in the lysates of isolated pancreatic acini. The results are representative of 4 independent (n=4) experiments. Results shown are the means ± SEM., * P< 0.05, comparing control, $ P<0.05 vs. Pir 3,5 alone. The generation of the active p34PAK2 form by the 3 hours incubation with CCK was also analyzed by western blotting (insert).